ACADEMIC AND RESEARCH PEER-REVIEWED MEDICAL JOURNALISSN 1727-2378
Ru
En

Improving Differential Diagnosis Techniques for Ovarian Neoplasms

DOI:10.31550/1727-2378-2018-150-6-40-43
Bibliography link: Ulyanova A. V., Ponomaryova Yu. N., Ashrafyan L. A. Improving Differential Diagnosis Techniques for Ovarian Neoplasms. Doctor.Ru. 2018; 6(150): 40–43.
Improving Differential Diagnosis Techniques for Ovarian Neoplasms
10 September 11:53

Study Objective: To assess the diagnostic value of the relative malignancy index (RMI) for differential diagnosis of true ovarian neoplasms compared with tumor-like lesions and processes.

Study Design: This was a prospective cohort study.

Materials and Methods: Comprehensive clinical and laboratory examination was performed on 259 participants, including 69 (26.6 ± 2.7%) healthy women, 126 (48.7 ± 3.1%) patients with benign ovarian masses, and 64 (24.7 ± 2.7%) patients with ovarian cancer. The mean age of the patients was 56.1 ± 19.1.

RMI was calculated for all patients. RMI values were interpreted using the following risk rating scale: < 25 = low risk for malignant changes, 25–200 = intermediate risk, and > 200 = high risk.

Study Results: More than 97.1% of the healthy women had RMI below 25; most of the women (>73.8%) with benign tumors or tumor-like lesions or processes had RMI between 25 and 200; while 83.9% of the patients with ovarian cancer had RMI above 200.

Conclusion: RMI can be used effectively in primary differential diagnosis, as a basic criterion for classifying patients with ovarian space-occupying lesions into risk groups for ovarian cancer. The index helps to improve medical and organizational management of this patient population.


A. V. Ulyanova — A. S. Loginov Moscow Clinical Scientific Center, Moscow City Department of Health. E-mail: 270679anastasiya@rambler.ru

Yu. N. Ponomaryova — A. S. Loginov Moscow Clinical Scientific Center, Moscow City Department of Health. E-mail: juliyapon@mail.ru

L. A. Ashrafyan — Academician V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow. E-mail: l_ashrafyan@oparina4.ru

Improving Differential Diagnosis Techniques for Ovarian Neoplasms
10 September 11:53
LITERATURE
  1. Нейштадт Э. Л., Ожиганова И. Н. Опухоли яичника. М.: Фолиант; 2014. 351 с. [Neishtadt E. L., Ozhiganova I. N. Opukholi yaichnika. M.: Foliant; 2014. 351 s. (in Russian)]
  2. Кулаков В. И., Прилепская В. Н., ред. Практическая гинекология. Клинические лекции. М.: МЕДпрес; 2006. 736 с. [Kulakov V. I., Prilepskaya V. N., red. Prakticheskaya ginekologiya. Klinicheskie lektsii. M.: MEDpres; 2006. 736 s. (in Russian)]
  3. Katz V. L., Lentz G. M., Lobo R. A. Benign gynecologic lesions: vulva, vagina, cervix, uterus, oviduct, ovary. In: Comprehensive gynecology. Philadelphia: Mosby; 2007: 419–71.
  4. Kuivasaari­Pirinen P., Anttila M. Ovarian cysts. Duodecim. 2011; 127(17): 1857–63.
  5. Полев Д., Баранова А. Диагностические биомаркеры в онкогинекологии: критический взгляд. Онкогинекология. 2012; 4: 4–12. [Polev D., Baranova A. Diagnosticheskie biomarkery v onkoginekologii: kriticheskii vzglyad. Onkoginekologiya. 2012; 4: 4–12. (in Russian)]
  6. Dodge J. E., Covens A. L., Lacchetti C., Elit L. M., Le T., Devries­Aboud M. et al. Preoperative identification of a suspicious adnexal mass: a systematic review and meta­analysis. Gynecol. Oncol. 2012; 126(1): 157–66. DOI: 10.1016/j.ygyno.2012.03.048
  7. Anton C., Carvalho F. M., Oliveira E. I., Maciel G. A. R., Baracat E. C., Carvalho J. P. A comparison of CA 125, HE 4, risk ovarian malignancy (ROMA) and risk malignace index (RMI) for the classification of ovarian masses. Clinics (Sao Paulo). 2012; 67(5): 437–41. DOI: 10.6061/clinics/2012(05)06
  8. Jacobs I., Oram D., Fairbanks J., Turner J., Frost C., Grudzinskas J. G. A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. Br. J. Obstet. Gynaecol. 1990; 97(10): 922–9.
  9. Karlsen M. A., Sandhu N., Høgdall C., Christensen I. J., Nederga­ard L., Lundvall L. et al. Evaluation of HE4, CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer in patients with a pelvic mass. Gynecol. Oncology. 2012; 127(2): 379–83. DOI: 10.1016/j.ygyno.2012.07.106
  10. Tingulstad S., Hagen B., Skjeldestad F. E., Onsrud M., Kiserud T., Halvorsen T. et al. Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre­operative diagnosis of pelvic masses. Br. J. Obstet. Gynaecol. 1996; 103(8): 826–31.
  11. NCI. National Institute for Health and Clinical Excellence: Ovarian cancer: recognition and initial management. Clinical guideline. https://www.nice.org.uk/guidance/cg122/resources/ovarian­cancer­recognition­and­initial­management­35109446543557 (дата обращения — 27.04.2018).
  12. Савельева Г. М., Сухих Г. Т., Серов В. Н., Радзинский В. Е., Манухин И. Б., ред. Гинекология. Национальное руководство. М.: ГЭОТАР­Медиа; 2017. 1048 с. [Savel'eva G. M., Sukhikh G. T., Serov V. N., Radzinskii V. E., Manukhin I. B., red. Ginekologiya. Natsional'noe rukovodstvo. M.: GEOTAR­Media; 2017. 1048 s. (in Russian)]
Similar article
18 October 09:57, Neurology
P.R. Kamchatnov, B.A. Abusueva, M.A. Evzelman, Z.Kh. Osmaeva, E.V. Mityaeva
Cytoflavin for Patients with Acute Ischemic Stroke
Doctor.Ru Neurology Psychiatry No. 6 (161), 2019
11 October 15:41, Interview
Interview

Academician G.T. Sukhikh 

Doctor.Ru Gynecology No. 11 (166), 2019

Partners