Improving Differential Diagnosis Techniques for Ovarian Neoplasms

Bibliography link: Ulyanova A. V., Ponomaryova Yu. N., Ashrafyan L. A. Improving Differential Diagnosis Techniques for Ovarian Neoplasms. Doctor.Ru. 2018; 6(150): 40–43.
Improving Differential Diagnosis Techniques for Ovarian Neoplasms
10 September 11:53

Study Objective: To assess the diagnostic value of the relative malignancy index (RMI) for differential diagnosis of true ovarian neoplasms compared with tumor-like lesions and processes.

Study Design: This was a prospective cohort study.

Materials and Methods: Comprehensive clinical and laboratory examination was performed on 259 participants, including 69 (26.6 ± 2.7%) healthy women, 126 (48.7 ± 3.1%) patients with benign ovarian masses, and 64 (24.7 ± 2.7%) patients with ovarian cancer. The mean age of the patients was 56.1 ± 19.1.

RMI was calculated for all patients. RMI values were interpreted using the following risk rating scale: < 25 = low risk for malignant changes, 25–200 = intermediate risk, and > 200 = high risk.

Study Results: More than 97.1% of the healthy women had RMI below 25; most of the women (>73.8%) with benign tumors or tumor-like lesions or processes had RMI between 25 and 200; while 83.9% of the patients with ovarian cancer had RMI above 200.

Conclusion: RMI can be used effectively in primary differential diagnosis, as a basic criterion for classifying patients with ovarian space-occupying lesions into risk groups for ovarian cancer. The index helps to improve medical and organizational management of this patient population.

A. V. Ulyanova — A. S. Loginov Moscow Clinical Scientific Center, Moscow City Department of Health. E-mail:

Yu. N. Ponomaryova — A. S. Loginov Moscow Clinical Scientific Center, Moscow City Department of Health. E-mail:

L. A. Ashrafyan — Academician V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow. E-mail:

Improving Differential Diagnosis Techniques for Ovarian Neoplasms
10 September 11:53
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